Treatment Options for Recurrent Non-Hodgkin Lymphoma

Treatment of indolent, recurrent adult non-Hodgkin lymphoma may include the following:

  • Chemotherapy with one or more drugs
  • Monoclonal antibody therapy
  • Radiolabeled monoclonal antibody therapy
  • Radiation therapy as palliative therapy to relieve symptoms and improve quality of life
  • A clinical trial of an autologous or allogeneic stem cell transplant


Treatment of aggressive, recurrent adult non-Hodgkin lymphoma may include the following:

  • Chemotherapy with or without stem cell transplant
  • Monoclonal antibody therapy with or without combination chemotherapy followed by autologous stem cell transplant
  • Radiation therapy as palliative therapy to relieve symptoms and improve quality of life
  • Radiolabeled monoclonal antibody therapy
  • CAR T-cell therapy
  • For mantle cell lymphoma, treatment may include the following:
    • Bruton's tyrosine kinase inhibitor therapy
    • Lenalidomide
    • A clinical trial of lenalidomide with monoclonal antibody therapy
    • A clinical trial comparing lenalidomide to other therapy
    • A clinical trial of proteasome inhibitor therapy (bortezomib)
  • A clinical trial of autologous or allogeneic stem cell transplant.


Treatment of indolent lymphoma that comes back as aggressive lymphoma depends on the type of non-Hodgkin lymphoma and may include radiation therapy as palliative therapy to relieve symptoms and improve quality of life. Treatment of aggressive lymphoma that comes back as indolent lymphoma may include chemotherapy.



Information provided by National Cancer Institute.


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